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Your Position: Accueil > Fc gamma RIIIB / CD16b (NA1)

Fc gamma RIIIB / CD16b (NA1)

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Cat . Non Espèces Description du produit Structure Pureté Caractéristique
CDB-H5296 Human Human Fc gamma RIIIB / CD16b (NA1) Protein, SUMO,His Tag (MALS & BLI-verified)
CDB-H5296-structure
CDB-H5296-sds
CDB-H82E4 Human Biotinylated Human Fc gamma RIIIB / CD16b (NA1) Protein, His,Avitag™ (SPR & BLI & MALS verified)
CDB-H82E4-structure
CDB-H82E4-sds
CDB-H5227 Human Human Fc gamma RIIIB / CD16b (NA1) Protein, His Tag (SPR & BLI & MALS verified)
CDB-H5227-structure
CDB-H5227-sds
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Part of Bioactivity data

CDB-H82E4-SPR
Human_FcRn_Heterodimer_Protein_SPR

Biotinylated Human CD16b (NA1), His,Avitag (Cat. No. CDB-H82E4) captured on Biotin CAP- Series S Sensor Chip can bind Herceptin with an affinity constant of 8.32 μM as determined in a SPR assay (Biacore T200) (QC tested).

Protocol
CDB-H82E4-SPR
Human_FcRn_Heterodimer_Protein_SPR

Immobilized Biotinylated Human CD16b (NA1), His,Avitag (Cat. No. CDB-H82E4) on SA Chip, can bind Herceptin with an affinity constant of 3.31 μM as determined in a SPR assay (Biacore T200) (Routinely tested).

Protocol

Synonym Name

Fc gamma RIIIB / CD16b (NA1),FCGR3B,CD16B,FCG3B,FCGR3,FCG3,IGFR3

Background

CD16 is a low affinity Fc receptor, and has been identified as Fc receptors FcγRIIIa (CD16a) and FcγRIIIb (CD16b). These receptors bind to the Fc portion of IgG antibodies. CD16 encoded by two different highly homologous genes in a cell type-specific manner.CD16 is found on the surface of natural killer cells, neutrophil polymorphonuclear leukocytes, monocytes and macrophages.CD16B is also kown as FCGR3B and FCG3B, is expressed specifically by polymorphonuclear leukocytes (neutrophils) and stimulated eosinophils. CD16B is the low affinity receptor for the Fc region of immunoglobulins gamma. FCGR3B binds complexed or aggregated IgG and also monomeric IgG. Contrary to III-A, FCG3B is not capable to mediate antibody-dependent cytotoxicity and phagocytosis. CD16B may serve as a trap for immune complexes in the peripheral circulation which does not activate neutrophils.

Clinical and Translational Updates

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